Curr Health Sci J, vol. 48, no. 4, 2022

Snail Immunoexpression in Endometrioid Endometrial Carcinomas

[Original Paper]

M.M. Florescu(1), O.I. Cretu(1), A. Muraru(1), D.N. Florescu(2), C.E. Simionescu(1)


(1)Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania,
(2)Department of Gastroenterology, University of Medicine and Pharmacy of Craiova, Romania


Abstract:

Endometrial carcinoma is one of the most prevalent cancers affecting women with epidemiological placing it as the sixth most common cancer in women. One of the factors implicated in EMT (epithelial-mesenchymal transition), Snail is regarded as having a pivotal role. We selected a number of 30 endometrial carcinomas, in a 2-year period (2020-2022). Snail immunoexpression was identified in the tumor cells for 70% of the endometroid carcinoma cases studied. Tumor cells showed both nuclear and cytoplasmic expression but only nuclear signals were quantified. The average percent of marked tumor cells was 38.6±24.9, corresponding to well differentiated carcinomas. Our analysis also showed a significant association between higher tumor grade and snail expression (p=0.000). Alteration of the epithelial-mesenchymal phenotype in endometrial carcinomas by Snail overexpression in high-grade and advanced-stage lesions constitutes mechanisms involved in the process of tumor progression.


Keywords:
Endometroid endometrial carcinoma, epithelial-mesenchymal transition, Snail, immunohistochemistry



Corresponding:
Dan Nicolae Florescu, Department of Gastroenterology, University of Medicine and Pharmacy of Craiova, Romania, e-mail: nicku.dan@gmail.com


DOI 10.12865/CHSJ.48.04.05 - Download PDF