Curr Health Sci J, vol. 49, no. 2, 2023

Epidural Extramedullary Plasmacytoma Successfully Treated with Surgical Excision and Bortezomib, Cyclophosphamide and Dexamethasone

[Case Report]

AE Martio(1), GJ Miotto(1), PM Mesquita Filho(1), WS Chaves(2), OR Karam(1)

(1)Neurosurgery Department, Hospital de Clínicas de Passo Fundo, Brazil,
(2)Hematology Department, Hospital de Clínicas de Passo Fundo, Brazil


Plasma cell neoplasms are common, accounting for more than 1% of all malignancies. Its most common form is multiple myeloma, but others, such as extramedullary plasmacytoma (EMP), exist. Spinal cord compression secondary to these pathologies is not uncommon, however, adjacent bone involvement is usually present. Spinal cord compression caused by isolated epidural EMP is extremely rare, with only one case reported to date. We describe the case of a 75-year-old female patient that presented with paraparesis, due to an isolated epidural EMP associated with light chain amyloidosis. She was treated with surgical decompression and neoadjuvant chemotherapy, and is currently with a 15-month disease-free period.

Plasma cell neoplasms, Plasmacytoma, Epidural neoplasms, Spinal cord compression, Immunoglobulin light-chain amyloidosis

Artur Eduardo Martio, Neurosurgery Department, Hospital de Clinicas de Passo Fundo, Brazil, Jorge Barbieux Street, 235, Cep 99062-570, RS, Brazil, e-mail:

DOI 10.12865/CHSJ.49.02.20 - Download PDF