CHSJ

Curr Health Sci J, vol. 49, no. 3, 2023

Mechanisms of Altered Immune Response in Skin Melanoma

[Review]

R.F. FRUNTEALATA(1), M. MATEI(2), I.K.S. BOBOC(3), S.I. MITRAN(4), M.E. CIUREA(5), G.A. STOICA(6)


(1)Ph.D. Student, University of Medicine and Pharmacy of Craiova, Romania;
(2)Department of Histology, University of Medicine and Pharmacy of Craiova, Romania;
(3)Experimental Research Center for Normal and Pathological Aging, University of Medicine and Pharmacy of Craiova, Romania;
(4)Department of Physiology, University of Medicine and Pharmacy of Craiova, Romania;
(5)Department of Plastic Surgery, University of Medicine and Pharmacy of Craiova, Romania;
(6)Department of Pediatric Surgery, University of Medicine and Pharmacy of Craiova, Romania


Abstract:

Melanoma, a deadly form of skin cancer, poses significant challenges to the host immune system, allowing tumor cells to evade immune surveillance and persist. This complex interplay between melanoma and the immune system involves a multitude of mechanisms that impair immune recognition and promote tumor progression. This review summarizes the intricate strategies employed by melanoma cells to evade the immune response, including defective immune recognition, immune checkpoint activation, and the role of regulatory T-cells, myeloid-derived suppressor cells, and exosomes in suppressing anti-tumor immunity. Additionally, we discuss potential therapeutic targets aimed at reversing immune evasion in melanoma, highlighting the importance of understanding these mechanisms for developing more effective immunotherapies. Improved insights into the interactions between melanoma and the immune system will aid in the development of novel treatment strategies to enhance anti-tumor immune responses and improve patient outcomes.


Keywords: Melanoma, skin cancer, immune response



Corresponding: Ianis Kevyn Stefan Boboc, Experimental Research Center for Normal and Pathological Aging, University of Medicine and Pharmacy of Craiova, Romania, e-mail: kevynboboc@gmail.com


DOI 10.12865/CHSJ.49.03.01 - Download PDF
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