CHSJ

Curr Health Sci J, vol. 49, no. 3, 2023

PLGA-The Smart Biocompatible Polimer: Kinetic Degradation Studies and Active Principle Release

[Original Paper]

M.V. CIOCILTEU(1), G. RAU(1), M.O. AMZOIU(1), D.C. AMZOIU(1), C.G. PISOSCHI(1), B.A.M. POENARIU(1)


(1)University of Medicine and Pharmacy of Craiova, Romania


Abstract:

The aim of our research was the development of prolonged delivery systems for therapeutic agents with various properties (prevention and treatment of bone diseases, anti-neoplastic, anti-inflammatory, antioxidant) that would ensure sustained therapeutic levels of the active principle, above the minimum inhibitory concentration, without reaching toxic levels over a long period of time as alternatives to conventional routes of administration. PLGA (poly lactic-co-glycolic acid), a biodegradable and biocompatible synthetic polymer, FDA approved, with a 65:35 lactic acid (LA): glycolic acid (GA) copolymer ratio, was chosen as delivery system. Our studies have shown that in PBS it undergoes two simultaneous degradation processes, hydrolysis and autohydrolysis, degrading completely in about 40 days. The release of the active principle is determined by the diffusion from inside the polymer matrix to the outside, which occurs simultaneously with the erosion of the polymer, during 35 days.


Keywords: PLGA, biocompatible, kinetic studies, release.



Corresponding: Corresponding Author


DOI 10.12865/CHSJ.49.03.15 - Download PDF
current issue cover Download cover
Download contents

Journal archive