CHSJ

Curr Health Sci J, vol. 49, no. 4, 2023

The Role of Neutrophil to Lymphocyte Ratio in the Assessment and Rehabilitation of Knee Osteoarthritis Patients

[Original Paper]

O.F. Fugaru(1), M.S. Serbanescu(2,3), M.R. Traistaru(3,4)


(1)PhD Student, University of Medicine and Pharmacy of Craiova, Romania,
(2)Department of Medical Informatics and Biostatistics, University of Medicine and Pharmacy of Craiova, Romania,
(3)Filantropia Clinical Municipal Hospital Craiova, Romania,
(4)Department of Physical and Rehabilitation Medicine, University of Medicine and Pharmacy of Craiova, Romania


Abstract:

Osteoarthritis (OA) is considered to be a real problem for many people. The last decade is characterized through an increased interest in using a non-specific, simply and readily available marker of inflammation-neutrophil to lymphocyte ratio (NLR)-to predict various chronic diseases (gastrointestinal and colorectal cancers, lung cancer, cardiovascular events, sarcoidosis, arthritis). The aim of our study is to establish the correlation between NLR and other parameters of clinical and functional status in KOA patients and to compare the NLR values before and after rehabilitation program. 90 patients, aged 40 to 82 years, diagnosed with mild (8 patients), moderate (70 patients) and severe (12 patients) KOA, in accordance with Kellgren and Lawrence score. Statistical assessment showed different values for the erythrocyte sedimentation (ESR) rate at 1-hour, Visual Analogue Scale (VAS), and Lequesne index in the studied group. NLR regression was significant for ESR at 1 and 2 hours. As an independent diagnostic marker, NLR has limited value, however it can be considered an inexpensive additional biomarker for the diagnosis of KOA and for monitoring the rehabilitation program.


Keywords: NLR, osteoarthritis, knee



Corresponding: Mircea Serbanescu, Department of Medical Informatics and Biostatistics, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania, e-mail: mircea_serbanescu@yahoo.com


DOI 10.12865/CHSJ.49.04.10 - Download PDF
current issue cover Download cover
Download contents

Journal archive