CHSJ

Curr Health Sci J, vol. 50, no. 2, 2024

Phenotypic Classification and Functional Assessment in Knee Osteoarthritis Patients

[Original Paper]

O. FUGARU(1), D. RADULESCU(2), M. SERBANESCU(3,4), M.R. TRAISTARU(4,5)


(1)PhD Student, University of Medicine and Pharmacy of Craiova, Romania;
(2)Department of Surgery, The Military Emergency Clinical Hospital ‘Dr. Stefan Odobleja’ Craiova;
(3)Department of Medical Informatics and Biostatistics, University of Medicine and Pharmacy of Craiova, Romania;
(4)Filantropia Clinical Municipal Hospital Craiova
(5)Department of Physical and Rehabilitation Medicine, Nursing Faculty, University of Medicine and Pharmacy of Craiova, Romania


Abstract:

The purpose of our study was the phenotypic classification of patients with osteoarthritis of the knee (KOA) and the dynamic assessment of functional status, monitored both numerically and in conformity with the International Classification of Functioning, Disability, and Health (ICF-basic set, shortened form). We conducted a prospective study in the Department of Physical Medicine and Rehabilitation, Filantropia Hospital, Craiova, from June of 2022 to November of 2023. In total, 100 patients with KOA were enlisted. Using data from the literature, physiotherapeutic examination, and results from paraclinical examinations, we classified studied patients into the five phenotypic categories: chronic pain (F1), local pathology with predominance of inflammatory mechanisms (F2), local pathology with predominance of metabolic mechanisms of bone and cartilage structures (F3), metabolic disorders (F4) and comorbidities (F5)-primarily chronic venous insufficiency in the lower limbs. We analyzed the values of generic qualifiers (at two evaluation time points) for the most significant elements of the core ICF set, abbreviated form, used in OAG, across each of the five phenotypes. Phenotypes F4 and F5 showed significant improvements across all evaluated functions, indicating increased efficacy in patients with comorbidities and metabolic diseases. Reduction in pain sensation, improvement in joint and muscle mobility, as well as enhancements in functions related to walking, dressing, and hand use, reflect an overall improvement in the quality of life for these patients.


Keywords: Knee, osteoarthritis, phenotypic categories, functional status.



Corresponding: Radulescu Dumitru, Department of Surgery, The Military Emergency Clinical Hospital Dr. Stefan Odobleja", Strada Caracal 150, 200749 Craiova, Romania, e-mail: dr_radulescu_dumitru@yahoo.com


DOI 10.12865/CHSJ.50.02.16 - Download PDF
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