CHSJ

Curr Health Sci J, vol. 50, no. 3, 2024

Is Serum Matrix Metalloproteinase 9 and/or D-Dimer Levels a Marker for Identifying Abdominal Aortic Aneurysms in Patients with Significant Coronary Atherosclerosis?

[Original Paper]

D.A. BRIE(1,2), A.M. JIANU(3), R. POPESCU(1,2), D.M. BRIE(4), M.BORUGA(5)


(1)Department of Cellular and Molecular Biology, "Victor Babe?" University of Medicine and Pharmacy, Timi?oara, Romania;
(2)ANAPATMOL Research Center, "Victor Babe?" University of Medicine and Pharmacy of Timisoara, 30041 Timisoara, Romania;
(3)Department of Anatomy and Embryology, "Victor Babe?" University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 30041 Timisoara, Romania;
(4)Department of Interventional Cardiology, Cardiovascular Disease Institute Timisoara, Gheorghe Adam St., No.13A, 30041 Timisoara, Romania;
(5)Department of Toxicology and Drug Industry, "Victor Babe?" University of Medicine and Pharmacy, Timi?oara, Romania


Abstract:

Our research aims to find a connection between the levels of MMP-9 and D-dimers in the blood and the prevalence of AAAs in subjects with atherosclerotic coronary disease. We selected fifty patients from each group and measured their MMP-9 and D-dimer levels in the blood. We discovered that in subjects with significant coronary disease and angina pectoris, the level of MMP-9 is higher compared to the subjects with angina pectoris but without significant coronary disease. When comparing this group with those with significant coronary disease and AAA, the level of MMP-9 is lower. Additionally, the D-dimer level was significantly higher in subjects with both AAA and significant coronary atherosclerosis compared to patients with significant coronary disease alone or those without significant coronary disease or AAAs. Subjects with significant coronary disease and AAA have elevated levels of MMP-9 and D-dimer compared to patients with significant coronary disease alone or without coronary artery disease or AAAs. These two factors could be used as indicators for diagnosing AAA in patients with angina pectoris.


Keywords: Aortic abdominal aneurysm, coronary artery disease, MMP-9 level, D-Dimer level.



Corresponding: Daniel Miron Brie, Department of Interventional Cardiology, Cardiovascular Disease Institute Timisoara, Gheorghe Adam St., No.13A, postal code 300310 Timisoara, Romania, e-mail: brie_daniel@yahoo.com


DOI 10.12865/CHSJ.50.03.07 - Download PDF
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