CHSJ

Curr Health Sci J, vol. 51, no. 2, 2025

Clinical and Radiological Spectrum in Cleidocranial Dysplasia: A Case Series

[Case Report]

F.M. DEBTA(1), K. AGARWAL(1), B. BERA(1), R. PANDA(1), S. MURMU(1)


(1)Department of Oral Medicine and Radiology, SCB Dental College and Hospital, Cuttack, Odisha, India


Abstract:

Cleidocranial dysplasia (CCD) is an autosomal dominant disorder caused by a mutation in Runt-related transcription factor 2 (RUNX2), primarily affecting bones undergoing intramembranous ossification, characterized by generalized dysplasia of bones and teeth. Affected individuals exhibit short stature, partial or complete absence of clavicles, delayed fontanel closure, open skull sutures, multiple wormian bones. Dental issues include retention of deciduous teeth, delayed eruption of permanent teeth, supernumerary teeth, absence of cellular cementum. Diagnosis is based on clinical & radiographic findings. Early diagnosis enhances treatment and quality of life. This case series presents spectrum of clinical radiographic findings of four adult CCD patients with varying dysplasia manifestations.


Keywords: Cleidocranial dysplasia, Cleidocranial dysostosis, CBFA1, RUNX2, wormian bones.



Corresponding: Basudha Bera, Department of Oral Medicine and Radiology, SCB Dental College and Hospital, Cuttack, Odisha, India, email: basudha25081996@gmail.com


DOI 10.12865/CHSJ.51.02.14 - Download PDF
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