CHSJ

Curr Health Sci J, vol. 52, no. 1, 2026

Metabolic and Inflammatory Disorders-Main Influencers of Psoriatic Arthritis Activity

[Original Paper]

L.I. SUIU(1), P.L. CIUREA(2), C.E. BITA(2), F. PORTA(3), F.A. VREJU(2)


(1)Doctoral School, University of Medicine and Pharmacy of Craiova, Romania;
(2)Department of Rheumatology, University of Medicine and Pharmacy of Craiova, Romania;
(3)Rheumatology section of the Interdisciplinary Pain medicine Unit of Santa Maria Maddalena Hospital in Occhiobello, Italy


Abstract:

Background: Psoriatic arthritis is a systemic, potentially severe condition associated with multiple comorbidities. It is characterized by peripheral and axial joint involvement, enthesitis, and association with various comorbidities. Objective: This study aims to identify some of the determinants of the severity of psoriatic arthritis. We studied the prevalence and common pathogenic mechanisms of various comorbidities associated with PsA. Methods: We studied 103 patients diagnosed with psoriatic arthritis. 69 met the inclusion criteria. We evaluated the disease activity index DAPSA, ESH, CRP, BMI, uric acid, cholesterol, triglycerides. Disease duration and type of joint involvement were also included. Results: The patients in the studied group had an average age of 54.75 (sd±10.02) years and there were 36 (55.38%) women. Duration of the diseases 8.254 (sd±5.307) years and an average of DAPSA values of 20.58 (sd±8.522). Clinical manifestations: 37 (56.92%) had peripheral damage; 6 (9.23%) had axial damage and 22 (33.85%) had mixed axial and peripheral damage. Inflammatory markers: ESR with an average serum value of 39.55 (sd±26.43) mm/h and average CRP values of 17.69mg/L (sd±28.71). The body mass index-an average value of 29.69Kg/m² (sd±5.979). Biological markers: uric acid with an average serum value of 9.832 mg/dl (sd±2.089), triglycerides 262.6 mg/dl (sd±41.58) and cholesterol 319.8mg/dl (sd±56.14). Conclusions: Serum levels of uric acid, cholesterol, triglycerides, ESR, and CRP influence psoriatic arthritis activity and response to treatment.


Keywords: Psoriatic arthritis, uric acid, dyslipidemia, metabolic syndrome.



Corresponding: Florentin Ananu Vreju, Department of Rheumatology, University of Medicine and Pharmacy of Craiova, Romania, e-mail: florentin.vreju@umfcv.ro


DOI 10.12865/CHSJ.52.01.06 - Download PDF
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