CHSJ

Curr Health Sci J, vol. 52, no. 3, 2026

PREVENT Versus the Pooled Cohort Equations: Implications for Contemporary Atherosclerotic Cardiovascular Risk Assessment

[Review]

K. ENGLISH(1), K.A. KUMAR(2), R. GARCIA(3)


(1)Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA;
(2)Department of Pediatrics, University of South Florida Morsani College of Medicine, Tampa, Florida, USA;
(3)Department of Internal Medicine, Creighton University Medical Center-Bergan Mercy, Omaha, NE 68124, USA


Abstract:

Background: Cardiovascular disease (CVD) encompasses multiple vascular conditions, including heart disease, stroke, and coronary artery disease, driven by traditional risk factors. Prompt identification of individuals at high risk of CVD is important for initiation of lifestyle modifications and pharmacotherapy to reduce the risk of major adverse cardiovascular events. Methods: Narrative evaluation of contemporary CVD risk prediction models, focusing on comparison between the PREVENT equation and prior Pooled Cohort Equations (PCE). Results: Multiple risk scores have been developed, including SCORE2 and PCE, with PREVENT introduced in 2023. The 2026 American College of Cardiology/American Heart Association dyslipidemia guideline now recommends using the PREVENT equation for CVD risk stratification. PREVENT provides updated risk estimates but introduces differences from PCE that may affect clinical decision-making. Conclusion: PREVENT represents a guideline-endorsed advancement in CVD risk prediction with potential advantages over PCE, though understanding its limitations is essential for appropriate application in clinical practice.


Keywords: Cardiovascular disease, PREVENT equation, ASCVD risk, dyslipidemia, heart failure, coronary artery disease, diabetes mellitus, hypertension.



Corresponding: Kevan English, Department of Internal Medicine, University of Nebraska Medical Center, 42nd and Emile St, Omaha, Nebraska 68198, USA, e-mail: keenglish@unmc.edu


DOI 10.12865/CHSJ.52.03.01 - Download PDF
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